We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Versatile Synthesis of Symmetric and Unsymmetric Imines via Photoelectrochemical Catalysis: Application to N‐Terminal Modification of Phenylalanine.
- Authors
Chiang, Chien‐Wei; Li, Hung‐Li; Lin, Ting‐Jun; Chen, Hung‐Chi; Chou, Yi‐Hsien; Chou, Chih‐Ju
- Abstract
A strategy that combines electrochemical synthesis and photoredox catalysis was reported for the efficient synthesis of imines. This approach was demonstrated to be highly versatile in producing various types of imines, including symmetric and unsymmetric imines, by exploring the impact of different substituents on the benzene ring of the arylamine. Additionally, the method was specifically applied to modify N‐terminal phenylalanine residues and was found to be successful in the photoelectrochemical cross‐coupling reaction between NH2‐Phe‐OMe and aryl methylamines, leading to the synthesis of phenylalanine‐containing imines. Therefore, this technique would present a convenient and efficient platform for synthesizing imines, with promising applications in chemical biology, drug development, and organic synthesis.
- Subjects
IMINES; CATALYSIS; CHEMICAL biology; ORGANIC synthesis; PHENYLALANINE; DRUG development; N-terminal residues
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 57, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202301379