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- Title
Recent advances in the histological and molecular classification of endometrial stromal neoplasms.
- Authors
Ferreira, Joana; Félix, Ana; Lennerz, Jochen K.; Oliva, Esther
- Abstract
This review addresses known features and recent developments in the histological, immunohistochemical, and molecular characterization of endometrial stromal neoplasms. We discuss the spectrum of these tumors, from the benign endometrial stromal nodule to low-grade endometrial stromal sarcoma to uterine undifferentiated sarcomas with a special emphasis on the expanding group of high-grade stromal sarcomas, recently added to the 2014 WHO classification, not only discussing the well-established YWHAE-FAM22 tumors but also two new groups, presenting with BCOR alterations including those with BCOR tandem internal duplications or NTRK fusions. It is likely that this high-grade category of endometrial stromal tumors will expand as increasing molecular data is available.
- Subjects
HISTOLOGY; IMMUNOHISTOCHEMISTRY; TUMORS; SARCOMA; ENDOMETRIAL tumors
- Publication
Virchows Archiv: European Journal of Pathology, 2018, Vol 473, Issue 6, p665
- ISSN
0945-6317
- Publication type
journal article
- DOI
10.1007/s00428-018-2470-6