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- Title
Toward an in vitro human pacemaker.
- Authors
Balducci, Valentina; Cerbai, Elisabetta
- Abstract
Regrettably, we know little about the human sinoatrial node (SAN); this is mainly due to the difficulty of obtaining human SAN tissue (surgeons rarely excise the SAN region during heart transplantation). Apart the discrepancies, availability of SAN-like human cardiomyocytes represents a promising tool for uncovering the (patho)physiology of heart beating and provides an effective in vitro human pacemaker. In the past, the idea of making biological pacemakers has been explored with the creation of genetically modified human mesenchymal stem cells expressing the cardiac pacemaker channel mHCN2 in such a way that once injected in the canine ventricular wall, they could deliver the heart with a biological pacemaker [[9]].
- Subjects
MUSCARINIC acetylcholine receptors; HUMAN embryonic stem cells; INDUCED pluripotent stem cells; SINOATRIAL node
- Publication
Pflügers Archiv: European Journal of Physiology, 2021, Vol 473, Issue 7, p989
- ISSN
0031-6768
- Publication type
Editorial
- DOI
10.1007/s00424-021-02585-4