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- Title
Bilateral symmetrical basal ganglia and thalamic lesions in children: an update (2015).
- Authors
Zuccoli, Giulio; Yannes, Michael; Nardone, Raffaele; Bailey, Ariel; Goldstein, Amy
- Abstract
Introduction: In children, many inherited or acquired neurological disorders may cause bilateral symmetrical signal intensity alterations in the basal ganglia and thalami. Methods: A literature review was aimed at assisting neuroradiologists, neurologists, infectious diseases specialists, and pediatricians to provide further understanding into the clinical and neuroimaging features in pediatric patients presenting with bilateral symmetrical basal ganglia and thalamic lesions on magnetic resonance imaging (MRI). Results: We discuss hypoxic-ischemic, toxic, infectious, immune-mediated, mitochondrial, metabolic, and neurodegenerative disorders affecting the basal ganglia and thalami. Conclusion: Recognition and correct evaluation of basal ganglia abnormalities, together with a proper neurological examination and laboratory findings, may enable the identification of each of these clinical entities and lead to earlier diagnosis.
- Subjects
DIAGNOSIS of brain diseases; BASAL ganglia; COMMUNICABLE diseases; MAGNETIC resonance imaging; METABOLIC disorders; MITOCHONDRIAL pathology; CEREBRAL anoxia-ischemia; THALAMUS; CHILDREN; WOUNDS &; injuries
- Publication
Neuroradiology, 2015, Vol 57, Issue 10, p973
- ISSN
0028-3940
- Publication type
Article
- DOI
10.1007/s00234-015-1568-7