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- Title
A Novel Application of Plasma and Cerebrospinal Fluid Level of Epstein Barr Virus DNA in the Diagnosis of Leptomeningeal Metastasis from Nasopharyngeal Carcinoma.
- Authors
Ma, Ada T. W.; Ma, Brigette B. Y.; Teo, Peter M. L.; Chan, Anthony T. C.
- Abstract
Epstein Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is endemic in Southeast Asia, and the plasma level of EBV DNA is a highly sensitive marker of disease recurrence following radiotherapy. Leptomeningeal recurrence from NPC is extremely rare and difficult to diagnose; only 4 cases have been reported in the literature. We report a case of leptomeningeal recurrence in NPC that was diagnosed using imaging and plasma and cerebrospinal fluid EBV DNA assays, followed by a review of the literature. Copyright © 2008 S. Karger AG, Basel
- Subjects
METASTASIS; EPSTEIN-Barr virus; NASOPHARYNX cancer; RADIOTHERAPY; CANCER relapse; CEREBROSPINAL fluid
- Publication
Oncology, 2008, Vol 74, Issue 1/2, p119
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000139140