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- Title
Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress.
- Authors
Fujii, Hideki; Nishijima, Fuyuhiko; Goto, Sumie; Sugano, Mikio; Yamato, Hideyuki; Kitazawa, Riko; Kitazawa, Sohei; Fukagawa, Masafumi
- Abstract
Background. Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease (CVD). Increased oxidative stress plays a role in the pathogenesis of CVD in CKD patients. The oral charcoal adsorbent AST-120 attenuates the progression of CKD possibly by removing uraemic toxins such as indoxyl sulfate (IS), and reduces oxidative stress. We investigated the relationship between oxidative stress and cardiac damage in CKD and its prevention by AST-120.
- Subjects
CHARCOAL; CHRONIC kidney failure; OXIDATIVE stress; HYPERTROPHY; CARDIOVASCULAR diseases
- Publication
Nephrology Dialysis Transplantation, 2009, Vol 24, Issue 7, p2089
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfp007