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- Title
ECTROMELIA VIRUS MULTIPLICATION IN REGENERATING MOUSE LIVER.
- Authors
Miller, J. F. A. P.; De Burgh, P. M.
- Abstract
The effect of ectromelia virus multiplication on the regenerating liver of partially hepatectomized mice has been studied using intravenous inocula of 109 L.D.50 doses. The rate of cell division at a period when maximal rate is normally expected, is less than normal as early as 10 hours after inoculation (that is towards the end of the eclipse period). This effect is even more marked at later periods, mitosis being rare after 20 hours of infection. The rate of virus multiplication in regenerating liver was found to be faster than in intact livers but the maximum titre reached was as high as that found in non-growing livers. The implications of these findings are discussed.
- Subjects
MICE; LIVER; INJECTIONS; CELL division; MITOSIS
- Publication
Australian Journal of Experimental Biology & Medical Science, 1957, Vol 35, Issue 2, p115
- ISSN
0004-945X
- Publication type
Article
- DOI
10.1038/icb.1957.14