We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Co-Relation of Hormonal Profile and BRCA1 in Sporadic Breast Carcinoma: A Single Institutional Experience of 303 Patients.
- Authors
Agarwal, Preeti; Khan, Fatima; Gupta, Sameer; Bhalla, Shalini; Thomas, Ann; Anand, Akshay; Singh, Kulranjan; Sonkar, Abhinav Arun
- Abstract
INTRODUCTION: Invasive Breast carcinoma--No special type (NST) is the most common breast malignancy accounting for 95% of breast cancers. Study of predictive and prognostic immunohistochemical markers estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (Her2neu) expression are crucial for treatment planning. MATERIALS AND METHODS: IN the present study we studied the hormonal profile in 303 sporadic breast cancers and BRCA1 protein expression in these patients along with its clinico-pathological correlation. RESULTS: In our patient population, Triple negative Breast carcinoma (TNBC) (104/303; 34.3%) was the most common luminal subtype followed by Luminal A 74/303; 24.4%), Her2 enriched (65/303; 21.5%), and Luminal B (60/303; 19.8%) respectively. This contrasts with many western studies which commonly report Luminal A being the largest subgroup. BRCA1 protein loss was more prominently seen in TNBC (64/104;61.5%) highlighting the possibility that high grade tumors are more susceptible to some epigenetic modifications leading to higher likelihood of loss of BRCA1 protein. CONCLUSION: Hence, we conclude that like hereditary cases of breast carcinoma with BRCA1 mutation; BRCA1 loss is also more likely in sporadic TNBC cases.
- Subjects
INDIA; STAINS &; staining (Microscopy); HORMONES; EPIDERMAL growth factor receptors; BRCA genes; IMMUNOHISTOCHEMISTRY; ONCOGENES; GENETIC testing; ESTROGEN receptors; GENE expression; DATA analysis software; BREAST tumors; PROGESTERONE receptors
- Publication
Clinical Pathology, 2022, Vol 15, p1
- ISSN
2632-010X
- Publication type
Article
- DOI
10.1177/2632010X221076379