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- Title
Operationalizing the centiloid scale for [<sup>18</sup>F]florbetapir PET studies on PET/MRI.
- Authors
Coath, William; Modat, Marc; Cardoso, M. Jorge; Markiewicz, Pawel J.; Lane, Christopher A.; Parker, Thomas D.; Keshavan, Ashvini; Buchanan, Sarah M.; Keuss, Sarah E.; Harris, Matthew J.; Burgos, Ninon; Dickson, John; Barnes, Anna; Thomas, David L.; Beasley, Daniel; Malone, Ian B.; Wong, Andrew; Erlandsson, Kjell; Thomas, Benjamin A.; Schöll, Michael
- Abstract
INTRODUCTION: The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by scanner differences, we investigated the Centiloid transformation with data from Insight 46 acquired with PET/magnetic resonanceimaging (MRI). METHODS: We transformed standardized uptake value ratios (SUVRs) from 432 florbetapir PET/MRI scans processed using whole cerebellum (WC) and white matter (WM) references, with and without partial volume correction. Gaussian‐mixture‐modelling–derived cutpoints for Aβ PET positivity were converted. RESULTS: The Centiloid cutpoint was 14.2 for WC SUVRs. The relationship between WM and WC uptake differed between the calibration and testing datasets, producing implausibly low WM‐based Centiloids. Linear adjustment produced a WM‐based cutpoint of 18.1. DISCUSSION: Transformation of PET/MRI florbetapir data to Centiloids is valid. However, further understanding of the effects of acquisition or biological factors on the transformation using a WM reference is needed. HIGHLIGHTS: Centiloid conversion of amyloid beta positron emission tomography (PET) data aims to standardize results.Centiloid values can be influenced by differences in acquisition.We converted florbetapir PET/magnetic resonance imaging data from a large birth cohort.Whole cerebellum referenced values could be reliably transformed to Centiloids.White matter referenced values may be less generalizable between datasets.
- Subjects
POSITRON emission tomography; MAGNETIC resonance imaging; COMPUTED tomography; WHITE matter (Nerve tissue); PETS
- Publication
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023, Vol 15, Issue 2, p1
- ISSN
2352-8729
- Publication type
Article
- DOI
10.1002/dad2.12434