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- Title
Germline Findings in Tumor-Only Sequencing: Points to Consider for Clinicians and Laboratories.
- Authors
Raymond, Victoria M.; Gray, Stacy W.; Roychowdhury, Sameek; Joffe, Steve; Chinnaiyan, Arul M.; Parsons, D. Williams; Plon, Sharon E.; Clinical Sequencing Exploratory Research Consortium Tumor Working Group
- Abstract
Precision oncology holds great potential to improve patient therapies and outcomes. Tumor sequencing is rapidly moving into clinical care as our understanding of the cancer genome and the availability of targeted therapies increase. Analysis of the cancer genome is most informative when paired with germline genomic DNA to delineate inherited and somatic variants. Although tumor-only analysis remains the most common methodology for numerous reasons, it holds the potential to identify clinically significant germline variants. Here, we provide anticipatory guidance and points to consider for laboratories and clinicians regarding the potential for germline findings in tumor sequencing.
- Subjects
GERM cells; TUMORS; CANCER; THERAPEUTICS; GENOMICS
- Publication
JNCI: Journal of the National Cancer Institute, 2016, Vol 108, Issue 4, p1
- ISSN
0027-8874
- Publication type
journal article
- DOI
10.1093/jnci/djv351