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- Title
Pre-Surgical Mood Predicts Memory Decline after Anterior Temporal Lobe Resection for Epilepsy.
- Authors
Busch, Robyn M.; Dulay, Mario F.; Kim, Kevin H.; Chapin, Jessica S.; Jehi, Lara; Kalman, Colleen C.; Naugle, Richard I.; Najm, Imad M.
- Abstract
This study examined pre-surgical depressed mood as a predictor of post-surgical memory change in adults who underwent temporal lobe resections (TLRs; n = 211). Patients completed the Wechsler Memory Scale-III and Beck Depression Inventory-Second Edition (BDI-II) before and after TLR (left = 110, right = 101) and were divided into two groups (clinically elevated depressive symptoms or not depressed) based on BDI-II score. Left-TLR patients with poorer pre-surgical mood had greater verbal memory declines after surgery compared with nondepressed left- or right-TLR patients and right-TLR patients with poor mood. Further, pre-surgical BDI-II score demonstrated incremental validity in predicting post-surgical memory change in left-TLR patients beyond pre-surgical memory scores. Differences in seizure outcome and post-surgical mood change could not account for memory decline. Results suggest that elevated pre-surgical depressive symptomatology is a risk factor for post-surgical memory decline and indicate that mood should be considered when advising patients about cognitive risks associated with temporal lobectomy. Results are discussed in terms of poor pre-surgical mood as an indicator of reduced cognitive reserve.
- Subjects
TEMPORAL lobectomy; EPILEPSY surgery; SURGERY &; psychology; MEMORY loss; DEPRESSED persons; WECHSLER Memory Scale; BECK Depression Inventory; MOOD (Psychology)
- Publication
Archives of Clinical Neuropsychology, 2011, Vol 26, Issue 8, p739
- ISSN
0887-6177
- Publication type
Article
- DOI
10.1093/arclin/acr067