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- Title
Clinicopathological characteristics of myelodysplastic syndromes with del(5q) in Taiwan.
- Authors
Ching-Fen YANG; Chih-Yi HSU; Liang-Tsai HSIAO; Shang-Wen CHEN; Shih-Sung CHUANG
- Abstract
Background: Myelodysplastic syndromes (MDS) are a group of clonal haematopoietic stem cell disorders characterised by ineffective haematopoiesis and cytopenia. Studies have reported differences in MDS between Asian and Western countries, but data from Taiwan are scarce. Materials and Methods: In this study we analysed the clinical and pathological features of 32 Taiwanese MDS patients with del(5q) (ie, del(5q) alone [Group A, n = 11], del(5q) with one additional cytogenetic abnormality other than monosomy 7 or del(7q) [Group B, del(5q)+1; n = 6], and del(5q) with =2 additional cytogenetic abnormalities [Group C, n = 15]). Results: Progression-free survival (PFS) and overall survival (OS) were more favourable for Group A than for Groups B (p < 0.05) and C (p ≤ 0.001). Multivariate analysis showed that age >70 years, thrombocytopenia, and karyotype other than del(5q) alone were poor prognostic factors. Among the patients that had World Health Organization (WHO)-defined MDS with isolated del(5q), one patient (9%) had a typical marrow morphology of 5q minus syndrome with erythroid hypoplasia and four patients (36%) had hypolobated megakaryocytes. In addition, PFS and OS were significantly more favorable for the patients with del(5q) alone than for those with del(5q)+1 (p < 0.05). Conclusion: The bone marrow morphology, clinical features, and prognosis of Taiwanese MDS patients with del(5q) were different from those associated with MDS with isolated del(5q) as defined in the current WHO classification. Researchers should compare different geographic regions and racial populations to determine whether geographic and racial differences exist with respect to MDS with del(5q.).
- Subjects
TAIWAN; WORLD Health Organization; MYELODYSPLASTIC syndromes; 5Q deletion syndrome; BONE marrow; HEMATOPOIETIC stem cells; PURE red cell aplasia; PROGRESSION-free survival
- Publication
Malaysian Journal of Pathology, 2023, Vol 45, Issue 3, p405
- ISSN
0126-8635
- Publication type
Article