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- Title
Influence of a Gas Exchange Correction Procedure on Resting Metabolic Rate and Respiratory Quotient in Humans.
- Authors
Galgani, Jose E.; Castro‐Sepulveda, Mauricio A.
- Abstract
<bold>Objective: </bold>The aim of this study was to determine the influence of a gas exchange correction protocol on resting metabolic rate (RMR) and respiratory quotient (RQ), assessed by a Vmax Encore 29n metabolic cart (SensorMedics Co., Yorba Linda, California) in overnight fasted and fed humans, and to assess the predictive power of body size for corrected and uncorrected RMR.<bold>Methods: </bold>Healthy participants (23 M/29 F; 34 ± 9 years old; 26.3 ± 3.7 kg/m2 ) ingested two 3-hour-apart glucose loads (75 g). Indirect calorimetry was conducted before and hourly over a 6-hour period. Immediately after indirect calorimetry assessment, gas exchange was simulated through high-precision mass-flow regulators, which permitted the correction of RMR and RQ values.<bold>Results: </bold>Uncorrected and corrected RMR and RQ were directly related at each time over the 6-hour period. However, uncorrected versus corrected RMR was 6.9% ± 0.5% higher (128 ± 7 kcal/d; P < 0.0001), while RQ was 14.0 ± 0.4% lower (-0.114 ± 0.003; P < 0.0001) when compared throughout the whole period. Body weight, sex, and age explained a larger fraction of the variance when corrected RMR was considered (adjusted R2 = 0.71; P < 0.0001) versus uncorrected RMR (adjusted R2 = 0.59; P < 0.0001).<bold>Conclusions: </bold>Applying a protocol to correct gas exchange in humans over a 6-hour period is feasible and provides information of improved accuracy.
- Subjects
PULMONARY gas exchange; RESPIRATORY quotient; INDIRECT calorimetry; ENERGY metabolism; BODY temperature regulation; BASAL metabolism; CALORIMETRY; QUESTIONNAIRES; PHYSIOLOGY
- Publication
Obesity (19307381), 2017, Vol 25, Issue 11, p1941
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.21981