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- Title
MTD: a mammalian transcriptomic database to explore gene expression and regulation.
- Authors
Xin Sheng; Jiayan Wu; Qianqian Sun; Xue Li; Feng Xian; Manman Sun; Wan Fang; Meili Chen; Jun Yu; Jingfa Xiao
- Abstract
A systematic transcriptome survey is essential for the characterization and comprehension of the molecular basis underlying phenotypic variations. Recently developed RNA-seq methodology has facilitated efficient data acquisition and information mining of transcriptomes inmultiple tissues/cell lines. Current mammalian transcriptomic databases are either tissue-specific or species-specific, and they lack in-depth comparative features across tissues and species. Here, we present amammalian transcriptomic database (MTD) that is focused on mammalian transcriptomes, and the current version contains data from humans, mice, rats and pigs. Regarding the core features, the MTD browses genes based on their neighboring genomic coordinates or joint KEGG pathway and provides expression information on exons, transcripts and genes by integrating theminto a genome browser. We developed a novel nomenclature for each transcript that considers its genomic position and transcriptional features. The MTD allows a flexible search of genes or isoforms with user-defined transcriptional characteristics and provides both table-based descriptions and associated visualizations. To elucidate the dynamics of gene expression regulation, the MTD also enables comparative transcriptomic analysis in both intraspecies and interspeciesmanner. The MTD thus constitutes a valuable resource for transcriptomic and evolutionary studies. The MTD is freely accessible at http://mtd.cbi.ac.cn.
- Subjects
GENETIC databases; GENETIC transcription; GENE expression; COMPUTER software
- Publication
Briefings in Bioinformatics, 2017, Vol 18, Issue 1, p28
- ISSN
1467-5463
- Publication type
Product Review
- DOI
10.1093/bib/bbv117