We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association Between β-Genus Human Papillomavirus and Cutaneous Squamous Cell Carcinoma in Immunocompetent Individuals-A Meta-analysis.
- Authors
Chahoud, Jad; Semaan, Adele; Yong Chen; Ming Cao; Rieber, Alyssa G.; Rady, Peter; Tyring, Stephen K.; Chen, Yong; Cao, Ming
- Abstract
<bold>Importance: </bold>Existing epidemiological evidence remains controversial regarding the association between β-genus human papillomavirus (β-HPV) and cutaneous squamous cell carcinoma (cSCC) in immunocompetent individuals.<bold>Objective: </bold>We aimed to clarify this association and evaluate type-specific β-HPV involvement.<bold>Data Sources: </bold>We performed a systematic literature search of MEDLINE and EMBASE for studies in humans through June 18, 2014, with no restriction on publication date or language. The following search terms were used: "human papillomavirus" and "cutaneous squamous cell carcinoma or skin squamous cell carcinoma or cSCC or nonmelanoma skin neoplasms."<bold>Study Selection: </bold>Articles were independently assessed by 2 reviewers. We only included case-control or cohort studies, in immunocompetent individuals, that calculated the odds ratio (OR) for cSCC associated with overall and type-specific β-HPV.<bold>Data Extraction and Synthesis: </bold>We first assessed the heterogeneity among study-specific ORs using the Q statistic and I2 statistic. Then, we used the random-effects model to obtain the overall OR and its 95% CI for all studies as well as for each type of HPV. We also tested and corrected for publication bias by 3 funnel plot-based methods. The quality of each study was assessed with the Newcastle Ottawa Scale.<bold>Main Outcomes and Measures: </bold>Pooled ORs and 95% CIs for overall β-HPV and HPV types 5, 8, 15, 17, 20, 24, 36, and 38 association with skin biopsy proven cSCC.<bold>Results: </bold>Seventy-nine articles were assessed for eligibility; 14 studies met inclusion criteria for the meta-analysis and included 3112 adult immunocompetent study participants with cSCC and 6020 controls. For all detection methods, the overall association between β-HPV and cSCC was significant with an adjusted pooled OR (95% CI) of 1.42 (1.18-1.72). As for the type-specific analysis, types 5, 8, 15, 17, 20, 24, 36, and 38 showed a significant association with adjusted pooled ORs (95% CIs) of 1.4 (1.18-1.66), 1.39 (1.16-1.66), 1.25 (1.04-1.50), 1.34 (1.19-1.52), 1.38 (1.21-1.59), 1.26 (1.09-1.44), 1.23 (1.01-1.50), and 1.37 (1.13-1.67) respectively. Our subgroup analysis in studies using only serology for HPV detection showed a significant association between overall β-HPV and HPV subtypes 5, 8, 17, 20, 24, and 38 with an increased risk of cSCC development.<bold>Conclusions and Relevance: </bold>This study serves as added evidence supporting β-HPV as a risk factor for cSCC in healthy individuals. The subgroup analysis highlights this significant association for HPV 5, 8, 17, 20, and 38, which may help to direct future prevention efforts.
- Subjects
COMPARATIVE studies; IMMUNE response; IMMUNOCOMPETENT cells; RESEARCH methodology; MEDICAL cooperation; META-analysis; PAPILLOMAVIRUS diseases; RESEARCH; SKIN tumors; SQUAMOUS cell carcinoma; VERTEBRATES; VIRUS diseases; EVALUATION research; DISEASE complications
- Publication
JAMA Dermatology, 2016, Vol 152, Issue 12, p1354
- ISSN
2168-6068
- Publication type
journal article
- DOI
10.1001/jamadermatol.2015.4530