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- Title
Ocular, Visual, and Anatomical Outcomes in Eyes Requiring Incisional Intraocular Pressure-Lowering Surgery Following the 0.19-mg Fluocinolone Acetonide Intravitreal Implant.
- Authors
Eichenbaum, David; Gonzalez, Victor H.; Roth, Daniel; Fortun, Jorge; Radcliffe, Nathan M.; Cutino, Antonio; Kasper, Jonathan; Coughlin, Brandon A.; Arevalo, J. Fernando
- Abstract
Background and Objective: To assess ocular, visual, and anatomical outcomes following the 0.19-mg fluocinolone acetonide (FAc) intravitreal implant (ILUVIEN®) and incisional intraocular pressure (IOP)-lowering surgery in diabetic macular edema. Patients and Methods: From a 36-month, phase 4, open-label, observational study (N = 202 eyes, 159 patients), 8 eyes (7 patients) required IOP-lowering surgery post-FAc; eyes were segregated by FAc-induced (n = 5, 2.47%) versus neovascular glaucoma (NVG)-related (n = 3, 1.49%) IOP elevations and assessed for IOP, best corrected visual acuity (BCVA), central subfield thickness (CST), and cup-to-disc ratio (c/d). Results: Changes at 36 months were +5.4 letters BCVA (P > 0.05) and +0.09 c/d (P = 0.0217); IOP and CST were unchanged. FAc-induced-group eyes required fewer IOP-lowering medications than NVG-group eyes (2.0 versus 4.0; P < 0.01) but for longer duration (15.2 versus 2.6 months; P < 0.001). Conclusions: Post-FAc IOP-lowering surgery, regardless of cause, largely did not affect the outcomes measured; these procedures, then, may not meaningfully threaten positive outcomes. [Ophthalmic Surg Lasers Imaging Retina 2024;55:22–29.]
- Subjects
OPHTHALMIC surgery; ARTIFICIAL implants; INTRAOCULAR lenses; MACULAR edema; VISUAL acuity
- Publication
Ophthalmic Surgery, Lasers & Imaging Retina, 2024, Vol 55, Issue 4, p22
- ISSN
2325-8160
- Publication type
Article
- DOI
10.3928/23258160-20231109-02