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- Title
Multiomics of three hematological malignancies in a patient reveal their origin from clonal hematopoietic stem cells.
- Authors
Mayeur, Sylvain; Molitor, Anne; Miguet, Laurent; Rigolot, Lucie; Naegely, Lydie; Stemmelen, Tristan; Meyer, Sébastien; Toussaint, Elise; Vallat, Laurent; Eischen, Alice; Chenard, Marie-Pierre; Tavian, Manuela; Bahram, Seiamak; Carapito, Raphael; Nicolae, Alina
- Abstract
It was involved by a CD30+ mature T cell lymphoma with cytotoxic phenotype consistent with ALK negative anaplastic large T cell lymphoma (ALK- ALCL) based on cytological assessment, immunophenotyping and PCR analysis of T-cell receptor gamma gene ( I TRG i ) rearrangements (Supplementary Fig. An excisional LN biopsy showed beside ALK- ALCL persistence, a diffuse large B-cell lymphoma (DLBCL-NOS) that was further confirmed by a monoclonal immunoglobulin kappa locus ( I IGK i ) rearrangement and an acute myeloid leukemia with monoblastic/monocytic differentiation (AML-M5) (Fig. 8389176 15 Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S. Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas. So far, CH involvement in the pathobiology of cytotoxic T-cell neoplasms has been only suspected, with recurrent I TET2 i and I DNMT3A i mutations documented in nodal cytotoxic peripheral T-cell lymphomas (TCL), some with history of B-cell lymphomas or MDS [[11]].
- Subjects
HEMATOLOGIC malignancies; HEMATOPOIETIC stem cells; MULTIOMICS; T-cell receptor genes; ANAPLASTIC large-cell lymphoma
- Publication
Blood Cancer Journal, 2023, Vol 13, Issue 1, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-023-00892-w