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- Title
High incidence of thromboembolism in patients with chronic GVHD: association with severity of GVHD and donor-recipient ABO blood group.
- Authors
El Jurdi, Najla; Elhusseini, Heba; Beckman, Joan; DeFor, Todd E.; Okoev, Grigori; Rogosheske, John; Lazaryan, Aleksandr; Weiler, Kristen; Bachanova, Veronika; Betts, Brian C.; Blazar, Bruce R.; Brunstein, Claudio G.; He, Fiona; Holtan, Shernan G.; Janakiram, Murali; Gangaraju, Radhika; Maakaron, Joseph; MacMillan, Margaret L.; Rashidi, Armin; Warlick, Erica D.
- Abstract
Chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic cell transplantation (HCT) is associated with systemic inflammation and endothelial dysfunction, increasing risk for thromboembolic events (TEE). In 145 adult recipients who developed cGVHD after a matched sibling or umbilical cord blood donor HCT from 2010 to 2018, 32(22%) developed at least 1 TEE event, and 14(10%) developed 2 TEE events. The 5-year cumulative incidence of TEE was 22% (95% CI, 15–29%) with a median time from cGVHD to TEE of 234 days (range, 12–2050). Median time to the development of LE DVT or PE was 107 (range, 12–1925) compared to 450 days (range, 158–1300) for UE DVT. Cumulative incidence of TEE was 9% (95% CI, 0–20%), 17% (95% CI, 9–25%), and 38% (95% CI, 22–55%) in those with mild, moderate, and severe GVHD, respectively. Higher risk for TEE was associated with cGVHD severity (hazard ratio [HR] 4.9, [95% CI, 1.1–22.0]; p = 0.03), non-O-donor to recipient ABO match compared to O-donor to O-recipient match (HR 2.7, [95% CI, 1.0–7.5]; p = 0.053), and personal history of coronary artery disease (HR 2.4, [95% CI, 1.1–5.3]; p = 0.03). TEE was not associated with 2-year non-relapse mortality or 5-year overall survival. Key points: Patients with chronic GVHD after allogeneic hematopoietic cell transplantation are at high risk for thromboembolic events occurring years after diagnosis. More severe chronic GVHD, non-O donor-recipient ABO compared to O-O match and personal history of coronary artery disease are associated with higher risk of thromboembolic events.
- Subjects
THROMBOEMBOLISM; DISEASE incidence; GRAFT versus host disease; ABO blood group system; HEMATOPOIETIC stem cell transplantation
- Publication
Blood Cancer Journal, 2021, Vol 11, Issue 5, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-021-00488-2