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- Title
An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model.
- Authors
Syam, Syamsiah; Chang, Chun-Wei; Lan, Wen-Chien; Ou, Keng-Liang; Huang, Bai-Hung; Lin, Yu-Yeong; Saito, Takashi; Tsai, Hsin-Yu; Chuo, Yen-Chun; Yang, Tzu-Sen; Liu, Chung-Ming; Hou, Ping-Jen
- Abstract
This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO4⋅0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit's artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.
- Subjects
PLATELET-rich plasma; BONE regeneration; BONE grafting; BONE growth; BONE density; RABBITS; MAXILLARY sinus
- Publication
Applied Sciences (2076-3417), 2021, Vol 11, Issue 11, p5271
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app11115271