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- Title
Synthesis and Antimicrobial Evaluation of a New Series of N-1,3 -Benzothiazol-2-ylbenzamides.
- Authors
Armenise, Domenico; Carocci, Alessia; Catalano, Alessia; Muraglia, Marilena; Defrenza, Ivana; De Laurentis, Nicolino; Rosato, Antonio; Corbo, Filomena; Franchini, Carlo
- Abstract
Enterococcus faecalis is a Gram-positive commensal inhabitant of the intestinal tract of humans, animals, and insects. However, it is also an opportunistic pathogen and has emerged as a leading cause of hospital-acquired extraintestinal infections. Fluoroquinolones have been frequently used to treat E. faecalis infections, and the emergence of fluoroquinolone-resistant E. faecalis strains has recently been reported in several countries. Thus, the identifications of new antibiotics specifically directed to E. faecalis may be envisaged. In this paper, a new series of N-1,3-benzothiazol-2-ylbenzamides have been designed, synthesized, and evaluated for their in vitro antimicrobial activities. Among the tested compounds, 3i was active against E. faecalis.
- Subjects
ANTI-infective agents; BENZOTHIAZOLE; BENZAMIDE; FLUOROQUINOLONES; CHEMICAL synthesis; ANTIBIOTICS
- Publication
Journal of Chemistry, 2013, p1
- ISSN
2090-9063
- Publication type
Article
- DOI
10.1155/2013/181758