We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Bone mineral density is negatively correlated with ulcerative colitis: a systematic review and meta‐analysis.
- Authors
Zhou, Tianyu; Pan, Jiaqi; Lai, Bin; Cen, Li; Jiang, Wenxi; Yu, Chaohui; Shen, Zhe
- Abstract
publisher‐imprint‐name Springer volume‐issue‐count 1 issue‐article‐count 18 issue‐toc‐levels 0 issue‐pricelist‐year 2020 issue‐copyright‐holder The Author(s) issue‐copyright‐year 2020 article‐contains‐esm No article‐numbering‐style Unnumbered article‐registration‐date‐year 2020 article‐registration‐date‐month 2 article‐registration‐date‐day 10 article‐toc‐levels 0 toc‐levels 0 volume‐type Regular journal‐product ArchiveJournal numbering‐style Unnumbered article‐grants‐type OpenChoice metadata‐grant OpenAccess abstract‐grant OpenAccess bodypdf‐grant OpenAccess bodyhtml‐grant OpenAccess bibliography‐grant OpenAccess esm‐grant OpenAccess online‐first false pdf‐file‐reference BodyRef/PDF/40169_2020_Article_270.pdf pdf‐type Typeset target‐type OnlinePDF issue‐type Regular article‐type ReviewPaper journal‐subject‐primary Medicine & Public Health journal‐subject‐secondary Medicine/Public Health, general journal‐subject‐collection Medicine open‐access true --> Background: Newer epidemiological studies suggest that the incidence of ulcerative colitis might be increasing rapidly. Furthermore, osteoporosis in ulcerative colitis patients has gained great attention, but the epidemiologic evidence remains controversial. Therefore, a meta‐analysis was performed to explore the association between bone density and ulcerative colitis. Methods: Two investigators used PubMed, EMBASE and the Cochrane Library databases to identify all studies published before August 2019. Depending on the outcomes, investigators divided these studies into four groups (OR, SMD [BMD], SMD [z‐score] and SMD [t‐score]). To address the use of steroids, which is a major confounding factor in this analysis, another subgroup analysis of studies of steroid‐free patients was conducted. Additionally, heterogeneity, sensitivity and stratified analyses were also performed. Results: A total of 13 cross‐sectional studies that involved 1154 participants were included in the present meta‐analysis, and three of them were included in the steroid‐free subgroup analysis. The pooled OR was 6.41 (95% CI 2.59–15.87) and the pooled SMD (BMD), SMD (t‐score) and SMD (z‐score) were − 0.24 (95% CI − 0.44 to − 0.04), − 0.55 (95% CI − 0.72 to − 0.37), and − 0.38 (95% CI − 0.56 and − 0.19), respectively. Since steroids are a significant confounder, the pooled SMD of the steroid‐free subgroup was − 0.55 (− 0.85 to − 0.25), which revealed a strong negative relationship between bone density and ulcerative colitis in steroid‐free patients. Additionally, other subgroup analyses also revealed a strong relationship. Conclusions: This meta‐analysis provides evidence for the potential association between ulcerative colitis and decreased bone density. It is essential for clinicians to consider bone mineral density in ulcerative colitis patients regardless of steroid‐therapy.
- Subjects
ULCERATIVE colitis; BONE density; METADATA; META-analysis; INFLAMMATORY bowel diseases
- Publication
Clinical & Translational Medicine, 2020, Vol 9, Issue 1, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1186/s40169-020-00270-0