We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Immune and Smooth Muscle Cells Interactions in Atherosclerosis: How to Target a Breaking Bad Dialogue?
- Authors
Ramel, Damien; Gayral, Stéphanie; Sarthou, Marie-Kerguelen; Augé, Nathalie; Nègre-Salvayre, Anne; Laffargue, Muriel
- Abstract
Inflammation is a well-known pathophysiological factor of atherosclerosis but its therapeutic targeting has long been ignored. However, recent advances in the understanding of the immune mechanisms implicated in atherosclerosis have unveiled several therapeutic targets currently undergoing clinical trials. These studies have also shed light on a dialogue between the immune compartment and vascular smooth muscle cells (VSMCs) that plays a critical role in atherosclerotic disease initiation, progression, and stabilization. Our review focuses on the link between cellular and soluble immune effectors and VSMC behavior at different phases of the pathology. Furthermore, we discuss the potential targeting of these interactions to efficiently prevent cardiovascular diseases.
- Subjects
SMOOTH muscle; MUSCLE cells; VASCULAR smooth muscle; ATHEROSCLEROSIS; CARDIOVASCULAR diseases
- Publication
Frontiers in Pharmacology, 2019, Vol 10, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2019.01276