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- Title
Dabrafenib‐induced neutrophilic panniculitis in a child undergoing dual BRAF‐MEK inhibitor therapy for glioblastoma multiforme.
- Authors
Young, Trevor K.; Gutierrez, Daniel; Criscito, Maressa C.; Kim, Randie H.; Lakdawala, Nikita; Oza, Vikash S.
- Abstract
BRAF inhibitor‐induced neutrophilic panniculitis is a rare event that is well‐characterized in adults undergoing therapy for metastatic melanoma. To date, there are very few reports of this event in children undergoing BRAF inhibitor therapy for low‐grade gliomas, all of which were seen with vemurafenib. We report a case of dabrafenib‐induced neutrophilic panniculitis in a 9‐year‐old girl that manifested within several weeks of initiating dual BRAF‐MEK inhibitor therapy for glioblastoma multiforme. This case highlights neutrophilic panniculitis as a side effect of dabrafenib in children and serves as a reminder to consider cutaneous side effects of BRAF inhibitors as they are increasingly used to treat children with primary brain tumors.
- Subjects
GLIOBLASTOMA multiforme; ADIPOSE tissue diseases; BRAIN tumors; YEAR; PYODERMA gangrenosum; DRUG side effects; CEREBELLAR tumors
- Publication
Pediatric Dermatology, 2020, Vol 37, Issue 6, p1185
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/pde.14306