We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine.
- Authors
Whale, R.; Quested, D. J.; Laver, D.; Harrison, P. J.; Cowen, P. J.
- Abstract
Abstract Rationale: A 44-base-pair insertion/deletion polymorphism in the promoter region of the human serotonin (5-HT) transporter (5-HTT) gene gives rise to a biallelic polymorphism designated long (l) and short (s). The s variant is associated with a lower expression of 5-HTT sites and a reduced efficiency of 5-HT reuptake. Objective: The aim of the present study was to determine whether the increase in brain 5-HT function produced by acute 5-HT reuptake blockade is influenced by the 5-HTT promoter Ils polymorphism. Methods: We measured the increase in plasma prolactin that follows acute administration of the tricyclic antidepressant clomipramine as an index of 5-HT neurotransmission in 14 healthy female subjects (7 with ss genotype and 7 with Il genotype) using a placebo-controlled crossover design. Results: Clomipramine-induced prolactin release was significantly greater in subjects with the Il genotype. Conclusion: Our findings suggest that acute 5-HT reuptake blockade produces a greater increase in 5-HT neurotransmission in subjects with the Il genotype than in those with an ss genotype. These results are consistent with clinical data indicating that subjects with an ss genotype may have a poorer therapeutic response to selective serotonin reuptake inhibitor (SSRI) monotherapy.
- Subjects
SEROTONIN; NEURAL transmission; PROLACTIN; ANTIDEPRESSANTS
- Publication
Psychopharmacology, 2000, Vol 150, Issue 1, p120
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s002130000432