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- Title
Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.
- Authors
Zhong, Y; El-Gamal, D; Dubovsky, J A; Beckwith, K A; Harrington, B K; Williams, K E; Goettl, V M; Jha, S; Mo, X; Jones, J A; Flynn, J M; Maddocks, K J; Andritsos, L A; McCauley, D; Shacham, S; Kauffman, M; Byrd, J C; Lapalombella, R
- Abstract
The article presents a study which evaluates the effects of Selinexor on leukemic cell proliferation in vivo and migration in chronic lymphocytic leukemia (CLL) cells using transgenic animals. It cites the mechanisms that control CLL cell survival and expansion which have prompted the rapid development of therapeutics that disrupt CLL-microenvironment interactions. It reveals that XPO1 inhibition prevents B-cell receptor (BCR)-induced survival to the protective stromal microenvironment.
- Subjects
CELL proliferation; CHRONIC lymphocytic leukemia; TRANSGENIC animals; THERAPEUTICS; B cells
- Publication
Leukemia (08876924), 2014, Vol 28, Issue 5, p1158
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/leu.2014.9