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- Title
Long-term follow-up of ETV6-RUNX1 ALL reveals that NCI risk, rather than secondary genetic abnormalities, is the key risk factor.
- Authors
Enshaei, A; Schwab, C J; Konn, Z J; Mitchell, C D; Kinsey, S E; Wade, R; Vora, A; Harrison, C J; Moorman, A V
- Abstract
The article discusses a study that evaluates the prognostic relevance of secondary abnormalities targeting the ETV6 and RUNX1 genes in children diagnosed with B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It shows that all patients have an excellent outcome when treated with contemporary regimens regardless with the presence of additional genetic abnormalities. It notes that the majority of ETV6-RUNX1 patients are negative in minimal residual disease (MRD).
- Subjects
LYMPHOBLASTIC leukemia in children; GENETIC disorders; B cells; GENE expression; THERAPEUTICS
- Publication
Leukemia (08876924), 2013, Vol 27, Issue 11, p2256
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/leu.2013.136