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- Title
Physiologically Based Pharmacokinetic (PBPK) Model-Informed Dosing Guidelines for Pediatric Clinical Care: A Pragmatic Approach for a Special Population.
- Authors
Freriksen, Jolien J. M.; van der Heijden, Joyce E. M.; de Hoop-Sommen, Marika A.; Greupink, Rick; de Wildt, Saskia N.
- Abstract
Physiologically based pharmacokinetic (PBPK) modeling can be an attractive tool to increase the evidence base of pediatric drug dosing recommendations by making optimal use of existing pharmacokinetic (PK) data. A pragmatic approach of combining available compound models with a virtual pediatric physiology model can be a rational solution to predict PK and hence support dosing guidelines for children in real-life clinical care, when it can also be employed by individuals with little experience in PBPK modeling. This comes within reach as user-friendly PBPK modeling platforms exist and, for many drugs and populations, models are ready for use. We have identified a list of drugs that can serve as a starting point for pragmatic PBPK modeling to address current clinical dosing needs.
- Subjects
PEDIATRIC therapy; CLINICAL medicine; PHARMACOKINETICS; PEDIATRIC physiology
- Publication
Pediatric Drugs, 2023, Vol 25, Issue 1, p5
- ISSN
1174-5878
- Publication type
Article
- DOI
10.1007/s40272-022-00535-w