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- Title
Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know.
- Authors
Alessandrino, Francesco; DiPiro, Pamela J.; Jagannathan, Jyothi P.; Babina, Gosangi; Krajewski, Katherine M.; Ramaiya, Nikhil H.; Giardino, Angela A.
- Abstract
Indolent B cell lymphomas are a group of lymphoid malignancies characterized by their potential to undergo histologic transformation to aggressive lymphomas. While different subtypes of indolent B cell lymphomas demonstrate specific clinical and imaging features, histologic transformation can be suspected on cross-sectional imaging when disproportionate lymph node enlargement or new focal lesions in extranodal organs are seen. On PET/CT, transformed indolent lymphoma may show new or increased nodal FDG avidity or new FDG-avid lesions in different organs. In this article, we will (1) review the imaging features of different subtypes of indolent B cell lymphomas, (2) discuss the imaging features of histologic transformation, and (3) propose a diagnostic algorithm for transformed indolent lymphoma. The purpose of this review is to familiarize radiologists with the spectrum of clinical and imaging features of indolent B cell lymphomas and to define the role of imaging in raising concern for transformation and in guiding biopsy for confirmation.
- Subjects
B cells; CANCER diagnosis; MUCOSA-associated lymphoid tissue lymphoma; HODGKIN'S disease; RADIOLOGISTS; CROSS-sectional imaging
- Publication
Insights into Imaging, 2019, Vol 10, Issue 1, p1
- ISSN
1869-4101
- Publication type
Article
- DOI
10.1186/s13244-019-0705-y