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- Title
Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial.
- Authors
Stranges S; Marshall JR; Natarajan R; Donahue RP; Trevisan M; Combs GF; Cappuccio FP; Ceriello A; Reid ME; Stranges, Saverio; Marshall, James R; Natarajan, Raj; Donahue, Richard P; Trevisan, Maurizio; Combs, Gerald F; Cappuccio, Francesco P; Ceriello, Antonio; Reid, Mary E
- Abstract
<bold>Background: </bold>Findings from animal models suggest that selenium supplementation improves glucose metabolism.<bold>Objective: </bold>To examine the effect of long-term selenium supplementation on the incidence of type 2 diabetes.<bold>Design: </bold>Secondary analysis of a randomized, double-blind, placebo-controlled trial.<bold>Setting: </bold>Areas of low selenium consumption of the eastern United States.<bold>Patients: </bold>1202 persons seen in dermatology clinics who did not have type 2 diabetes at baseline.<bold>Intervention: </bold>Oral administration of selenium, 200 microg/d, or placebo.<bold>Measurements: </bold>Incidence of type 2 diabetes.<bold>Results: </bold>During an average follow-up of 7.7 years (SD, 2.7), type 2 diabetes developed in 58 selenium recipients and 39 placebo recipients (incidence, 12.6 cases per 1000 person-years vs. 8.4 cases per 1000 person-years, respectively; hazard ratio, 1.55 [95% CI, 1.03 to 2.33]). The lack of benefit of selenium supplementation on the incidence of type 2 diabetes persisted in analyses stratified by age, sex, body mass index, and smoking status. An exposure-response gradient was found across tertiles of baseline plasma selenium level, with a statistically significantly increased risk for type 2 diabetes in the highest tertile of baseline plasma selenium level (hazard ratio, 2.70 [CI, 1.30 to 5.61]).<bold>Limitations: </bold>Diabetes was a secondary outcome in the parent trial. Diagnoses of diabetes were self-reported but were validated in most participants. The sample was mostly older and white.<bold>Conclusions: </bold>Selenium supplementation does not seem to prevent type 2 diabetes, and it may increase risk for the disease. Click here for related information on selenium.
- Publication
Annals of Internal Medicine, 2007, Vol 147, Issue 4, p217
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-147-4-200708210-00175