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- Title
Renal Hücreli (Berrak Hücreli Tip) Karsinomlarda Cox-2 Ekspresyonu ve Mikrodamar Yoğunluğu.
- Authors
Güçer, Hasan; Şahan, Elife; İğdem, Ayşenur Akyildiz; Tetıkkurt, Ü. Seza; Erdoğan, Nusret
- Abstract
Objective: Overexpression of cyclooxygenase-2 (COX-2) and its association with angiogenesis have been shown in various carcinomas. In this study, we investigated COX-2 expression in clear cell type renal cell carcinoma and its association with microvessel density and various clinicopathologic parameters. Material and Method: Fifty cases of clear cell type renal cell carcinoma that underwent radical nephrectomy were included in this study. The status of COX-2 expression was examined immunohistochemically. Microvessel density in the neoplasm was estimated using the computerized image-analizer system. We evaluated the correlation between COX-2 expression, microvessel density and clinicopathologic findings. Results: COX-2 expression was observed in 76% of the cases. There was no association between COX-2 expression and microvessel density, age, sex, tumor size, nuclear grade and stage (p>0.05). Conclusion: Most clear cell type renal cell carcinomas expressed COX-2, but there was no relationship between COX-2 and various clinicopathologic parameters. Similar studies to explore therapeutic agents that target these specialities can be useful in the treatment of renal cell carcinomas which show COX-2 expression and high vascularity.
- Subjects
CANCER treatment; RENAL cell carcinoma; CYCLOOXYGENASES; KIDNEY diseases; NEOVASCULARIZATION; TUMORS; IMMUNOHISTOCHEMISTRY; THERAPEUTICS
- Publication
Turkish Journal of Pathology, 2009, Vol 25, Issue 2, p13
- ISSN
1018-5615
- Publication type
Article
- DOI
10.5146/tjpath.2009.00966