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- Title
Radiation induced liver disease: is hereditary haemochromatosis a risk factor?
- Authors
Laurie, R. M.; Chao, M. W. T.; Dow, C. A.
- Abstract
A 71-year-old man with Stage II gastric cancer developed rapid onset radiation induced liver disease after ceasing adjuvant chemotherapy and radiotherapy. Autopsy revealed moderate hepatocellular iron overload. Posthumously, he was found to be a compound heterozygote for hereditary haemochromatosis. Since both radiation and iron overload may induce liver damage through the activation of hepatic stellate cells, it is possible that hepatocellular iron overload may potentiate the effects of irradiation and predispose the patient to radiation induced liver disease.
- Publication
Journal of Radiotherapy in Practice, 2003, Vol 3, Issue 2, p101
- ISSN
1460-3969
- Publication type
Article
- DOI
10.1017/S1460396903000086