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- Title
Accumulation of copper and generation of hydroxyl radicals of hepatocellular carcinoma.
- Authors
Fukuda, Hiroyuki; Ebara, Masaaki; Arimoto, Manaka; Obu, Masamichi; Kin, Shinnen; Yoshikawa, Masaharu; Sugura, Nobuyuki; Saisho, Hiromitsu; Yukawa, Masae; Ikota, Nobuo; Ozawa, Toshihiko; Ogura, Yasumitsu; Suzuki, Kazuo
- Abstract
Evaluates the connection between the progression of hepatic fibrosis and trace metals, and the generation of hydroxyl radicals from copper-metallothionein purified from human hepatocellular carcinoma. Measurement of the metal content of liver using proton-induced x-ray emission; Evaluation of distribution profiles of copper and zinc in human liver by high-performance liquid chromatography.
- Subjects
LIVER cancer; HYDROXYL group; METALLOTHIONEIN; PROTON-induced X-ray emission; HIGH performance liquid chromatography
- Publication
International Journal of PIXE, 2001, Vol 11, Issue 3/4, p111
- ISSN
0129-0835
- Publication type
Article
- DOI
10.1142/S0129083501000165