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- Title
Puberty and pubertal growth dynamics in children with idiopathic short stature.
- Authors
Mariani, Aude; Jeandel, C.; Paris, F.; Ecochard, R.
- Abstract
Objective: As the prognosis for final height is unfavorable for children with idiopathic short stature (ISS), we studied the pubertal growth dynamics in these children, which is a determinant factor in final height. Subjects/methods: In a retrospective cohort study, we analyzed the pubertal period, age of puberty and peripubertal growth in 50 children with ISS. Results: The onset of puberty occurred later. Growth rate tended to become increasingly subnormal in the prepubertal period and height was -2.45 SD at puberty onset. Growth reaccelerated at this point, which tended to correct the deviation from the mean height, but it was insufficient to obtain a normal final height. Conclusions: The dynamics of growth in children with ISS showed a distinct pattern in the prepubertal and pubertal periods and puberty is significantly delayed in this population. These patterns could explain the unfavorable prognosis for children with ISS.
- Subjects
SHORT stature; PUBERTY; GROWTH rate; AGE; PROGNOSIS
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2011, Vol 24, Issue 5/6, p319
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem.2011.031