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- Title
Biochemical verification of tobacco use and cessation.
- Authors
Benowitz, Neal L.; Jacob III, Peyton; Ahijevych, Karen; Jarvis, Martin J.; Hall, Sharon; LeHouezec, Jacques; Hansson, Anna; Lichtenstein, Ed; Henningfield, Jack; Tsoh, Janice; Hurt, Richard D.; Velicer, Wayne
- Abstract
The charge of our subcommittee was to assess the utility of biomarkers of tobacco use and cessation and make recommendations for their application in clinical trials. The committee addressed five specific questions: 1. Which biochemical markers are most useful for assessing tobacco use, with regards to smoking cessation, smoking cessation given other tobacco use, and concurrent use of nicotine medication to aid cessation? 2. What are optimal cut-off points for biomarker values to distinguish tobacco use vs. no tobacco use, with consideration given to data on specificity and sensitivity at various cut-points and influence of ethnicity? 3. What is an acceptable time window between self-reported last smoking and biochemical verification for different biomarkers? 4. What is the utility (and limitation) of using biochemical markets as indicators of severity of addiction'? 5. When is biochemical validation necessary?
- Subjects
BIOMARKERS; PREVENTION of tobacco use; SMOKING cessation
- Publication
Nicotine & Tobacco Research, 2002, Vol 4, Issue 2, p149
- ISSN
1462-2203
- Publication type
Article
- DOI
10.1080/14622200210123581