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- Title
Management of ADA-Deficient SCID Patient on Adagen During Pregnancy.
- Authors
Shams, Marissa; Kobrynski, Lisa
- Abstract
We describe the management of a patient with ADA-deficient Severe Combined Immune Deficiency maintained on PEG-ADA treatment throughout her pregnancy. ADA-deficient SCID (ADA-SCID) is rare but accounts for approximately 15% of all SCID cases. As a result of improved outcomes with definitive treatment such as hematopoietic cell transplant (HCT) and now gene therapy, few patients remain on long-term therapy with weekly PEG-ADA enzyme replacement alone. Knowledge detailing the management of ADA-SCID patients on PEG-ADA replacement during pregnancy is valuable to clinical immunologists.
- Subjects
SEVERE combined immunodeficiency; PREGNANCY; BLOOD cell count
- Publication
Journal of Clinical Immunology, 2019, Vol 39, Issue 8, p846
- ISSN
0271-9142
- Publication type
Letter
- DOI
10.1007/s10875-019-00692-7