We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Acute Hemolytic Transfusion Reaction Due to Pooled Platelets: A Rare but Serious Adverse Event.
- Authors
Gammon, Richard; Cook, Susan; Trinkle, Anthony; Thomas, Korena; Benson, Kaaron
- Abstract
A female patient aged 65 years with blood group A with relapsed lymphoma had thrombocytopenia; leukocyte-reduced group O prestorage pooled platelet concentrates (PPLTs) were transfused without adverse events. She was discharged home, but 1.5 hours later she returned with fever and dark urine. Hypotension and tachycardia developed; she was admitted to the intensive care unit. Post-transfusion blood and urine samples were obtained. Serial dilutions from 5 donor testing tubes and a simulated PLT pool were performed and read at immediate spin and IgG. Testing confirmed an acute hemolytic transfusion reaction (AHTR): elevated lactate dehydrogenase (996 U/L; normal range 135 U/L–225 U/L) and undetectable haptoglobin (<10 mg/dL; normal range 30 mg/dL–200 mg/dL) levels. Urinalysis showed dark amber urine but no significant quantity of red blood cells. At 37ºC the simulated pool and donor number 5 had high-titer anti-A. As a precaution, the donor was permanently deferred. Research has shown that PLT-associated AHTR has occurred with apheresis platelets but is very rare with whole blood–derived PLTs.
- Subjects
BLOOD platelets; BLOOD transfusion; HEMOLYSIS &; hemolysins; CANCER chemotherapy; BLOOD transfusion reaction; LACTATE dehydrogenase; ADVERSE health care events; THROMBOCYTOPENIA; LYMPHOMAS; URINALYSIS; BLOOD group incompatibility
- Publication
Laboratory Medicine, 2021, Vol 52, Issue 2, p202
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmaa056