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- Title
Cytokine Levels in Midtrimester Amniotic Fluid in Normal Pregnancy and in the Prediction of Pre-eclampsia.
- Authors
Heikkinen, J.; Möttönen, M.; Pulkki, K.; Lassila, O.; Alanen, A.
- Abstract
Midtrimester amniotic fluid cytokines may reflect the function of the maternal immune system in the maternal–fetal interface and thus be predictive of pre-eclampsia. We determined the concentrations of interleukin (IL)-6, IL-8, IL-10, IL-11, IL-12, IL-15, tumour necrosis factor (TNF)-α and transforming growth factor (TGF)-β in amniotic fluid at 14–16 weeks of gestation from women with normal pregnancies and from those who subsequently developed severe pre-eclampsia. The concentrations of the cytokines in amniotic fluid did not significantly differ between patients and normal controls. The median concentration of IL-6 was 950 pg/ml in normal pregnant women and 578 pg/ml in the patient group. The median concentration of IL-8 was 606 pg/ml in normal controls and 294 pg/ml in the patient group. The levels of IL-6, IL-8 and TGF-β correlated positively with each other. TNF-α concentrations were low and similar in both groups. IL-10 and IL-12 were detected at very low levels in 37 and 7% of the samples, respectively. No difference was found in IL-15 concentrations between the groups. IL-11 was found only at low levels in both groups. Although none of the cytokines measured was predictive of pre-eclampsia, this study provides information of cytokines in amniotic fluid during the period when the spiral arteries are remodelled.
- Subjects
AMNIOTIC liquid; INTERLEUKINS; TUMOR necrosis factors; TRANSFORMING growth factors-beta
- Publication
Scandinavian Journal of Immunology, 2001, Vol 53, Issue 3, p310
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.2001.00872.x