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- Title
An In Vitro Model for the Expansion of Vγ9δ2 T Lymphocytes During Development.
- Authors
Wilhelm, M.; Tony, H.-P.
- Abstract
The γ/δT lymphocytes represent a minority of T lymphocytes in human peripheral blood. Although there have been reports of reactivity against (myco-) bacterial antigens and heat shock proteins, their function and antigen specificity remain ill defined. The biological role of γ/δ T cells has been related to functions within the 'first line of defense'. Similar to γ/δ T lymphocytes in the T-cell compartment, CD5 positive B cells represent a small subset of B lymphocytes, which is thought to be involved in the maintenance of natural immunity and autoimmunity. We provide evidence for the cooperation of γ/δ T cells and CD5 positive B cells in the proliferative response of γ/δ T cells to bacterial antigens. Our data indicate a strong proliferation of Vγ9δ2 T cells in response to gram-negative bacteria, which is dependent upon the presence of CD5 positive B-CLL or activated normal B lymphocytes. The selective stimulation of the Vγ9δ2 subpopulation by gram-negative bacteria is also confirmed by analysis of different γ/δ T-cell clones. The interaction of γ/δ T cells with activated B cells and gram-negative bacteria may prove to be a useful model similar to the expansion of the Vγ9δ2 subpopulation during development. In addition, our <em>in vitro</em> system should provide new insights in the interaction of CLL B cells with the immune system and the antigens recognized by γ/δ T cells.
- Subjects
LYMPHOCYTES; BACTERIA; CELLS; T cells; IMMUNITY; B cells; GRAM-negative bacteria; LEUCOCYTES; ANTIGENS; ANTIGEN presenting cells; PROKARYOTES; FUNGUS-bacterium relationships
- Publication
Scandinavian Journal of Immunology, 1994, Vol 40, Issue 5, p521
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1994.tb03499.x