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- Title
A Novel Function for Foxm1 in Interkinetic Nuclear Migration in the Developing Telencephalon and Anxiety-Related Behavior.
- Authors
Xiaojing Wu; Xiaochun Gu; Xiaoning Han; Ailing Du; Yan Jiang; Xiaoyun Zhang; Yanjie Wang; Guangliang Cao; Chunjie Zhao
- Abstract
Interkinetic nuclear migration (INM) is a key feature of cortical neurogenesis. INM functions to maximize the output of the neuroepithelium, and more importantly, balance the self-renewal and differentiation of the progenitors. Although INM has been reported to be highly correlated with the cell cycle, little is known about the effects of cell cycle regulators on INM. In this study, by crossing Foxm1fl/fl mice with Emx1-Cre line, we report that a conditional disruption of forkhead transcription factor M1 (Foxm1) in dorsal telencephalon results in abnormal cell cycle progression, leading to impairedINMthrough the downregulation of Cyclin b1 and Cdc25b. The impairment of INM disturbs the synchronization of apical progenitors (APs) and promotes the transition from APs to basal progenitors (BPs) in a cell-autonomous fashion. Moreover, ablation ofFoxm1causes anxiety-related behaviors in adulthood. Thus, this study provides evidence of linkages among the cell cycle regulator Foxm1, INM, and adult behavior.
- Subjects
TELENCEPHALON; ANXIETY; DEVELOPMENTAL neurobiology; AUTOPOIESIS; PROGENITOR cells; PSYCHOLOGY of adults; CYCLINS
- Publication
Journal of Neuroscience, 2014, Vol 34, Issue 4, p1510
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2549-13.2014