We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Involvement of cytotoxic granules in the apoptosis of aplastic anaemia.
- Authors
Xu, J. L.; Nagasaka, T.; Nakashima, N.
- Abstract
Summary. To study the involvement of cytotoxic granules in apoptosis of aplastic anaemia (AA), we analysed bone marrow clot sections of AA for apoptosis and perforin, granzyme B and T-cell intracellular antigen-1 (TIA-1) expression. Perforin, TIA-1 expression and apoptosis were significantly increased in AA patients compared with control subjects, but granzyme B was not. TIA-1 was significantly correlated with apoptotic cells of AA. No correlation was found between perforin and apoptotic cells of AA. These results suggest that perforin and TIA-1 play a role in the pathogenesis of AA. TIA-1 is implicated as an effector in the apoptosis of AA.
- Subjects
CELL-mediated cytotoxicity; APOPTOSIS; APLASTIC anemia
- Publication
British Journal of Haematology, 2003, Vol 120, Issue 5, p850
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2003.04147.x