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APOE ε4's impact on response to amyloid therapies in early symptomatic Alzheimer's disease: Analyses from multiple clinical trials.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 12, p. 5407, doi. 10.1002/alz.13128
By:
- Evans, Cynthia D.;
- Sparks, JonDavid;
- Andersen, Scott W.;
- Brooks, Dawn A.;
- Hauck, Paula M.;
- Mintun, Mark A.;
- Sims, John R.
Publication type:
Article
Reproducibility of applying multiple statistical analyses to data from the TRAILBLAZER‐ALZ clinical trial of donanemab in early symptomatic Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.057700
By:
- Sparks, JonDavid;
- Lo, Albert C.;
- Evans, Cynthia Duggan;
- Chatterjee, Saptarshi;
- Andersen, Scott W.;
- Sims, John R.;
- Brys, Mirek;
- Mintun, Mark A
Publication type:
Article
TRAILBLAZER‐ALZ Study: Dynamics of amyloid reduction after donanemab treatment.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.057492
By:
- Shcherbinin, Sergey;
- Andersen, Scott W.;
- Evans, Cynthia Duggan;
- Lo, Albert C.;
- Lu, Ming;
- Navitsky, Michael;
- Collins, Emily C;
- Sims, John R.;
- Brooks, Dawn A.;
- Mintun, Mark A
Publication type:
Article
Novel use of tau imaging to enrich for pathological homogeneity within the PERISCOPE‐ALZ study of zagotenemab.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.050173
By:
- Munsie, Leanne M;
- Lo, Albert C.;
- Fleisher, Adam S;
- Andersen, Scott W.;
- Shcherbinin, Sergey;
- Sims, John R.;
- Brys, Mirek;
- Mintun, Mark A
Publication type:
Article
Reasons for study exclusion by sex in lanabecestat studies AMARANTH and DAYBREAK‐ALZ: Human/Human trials: Other.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.038663
By:
- Zimmer, Jennifer A.;
- Andersen, Scott W.;
- Wessels, Alette M.;
- Shering, Craig;
- Sims, John R.
Publication type:
Article
Cognitive outcomes in trials of two BACE inhibitors in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1483, doi. 10.1002/alz.12164
By:
- Wessels, Alette M.;
- Lines, Christopher;
- Stern, Robert A.;
- Kost, James;
- Voss, Tiffini;
- Mozley, Lyn Harper;
- Furtek, Christine;
- Mukai, Yuki;
- Aisen, Paul S.;
- Cummings, Jeffrey L.;
- Tariot, Pierre N.;
- Vellas, Bruno;
- Dupre, Nicole;
- Randolph, Christopher;
- Michelson, David;
- Andersen, Scott W.;
- Shering, Craig;
- Sims, John R.;
- Egan, Michael F.
Publication type:
Article
FTS3‐01‐03: PERFORMANCE ON EXPLORATORY EFFICACY VARIABLES IN AMARANTH, A RANDOMIZED PHASE 2/3 STUDY IN EARLY ALZHEIMER'S DISEASE WITH LANABECESTAT.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P873, doi. 10.1016/j.jalz.2019.06.4620
By:
- Stern, Robert A.;
- Wessels, Alette M.;
- Selzler, Katherine J.;
- Andersen, Scott W.;
- Mullen, Jamie;
- Sims, John R.
Publication type:
Article
FTS3‐01‐02: SUBGROUP POPULATIONS IN AMARANTH, A RANDOMIZED PHASE 2/3 STUDY IN EARLY ALZHEIMER'S DISEASE WITH LANABECESTAT.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P872, doi. 10.1016/j.jalz.2019.06.4619
By:
- Tariot, Pierre N.;
- Selzler, Katherine J.;
- Wessels, Alette M.;
- Andersen, Scott W.;
- Mullen, Jamie;
- Zimmer, Jennifer A.;
- Sims, John R.
Publication type:
Article
P1‐369: AMYLOID RELATED IMAGING ABNORMALITIES AND OTHER MRI FINDINGS IN THE A4 SCREENING POPULATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P394, doi. 10.1016/j.jalz.2019.06.924
By:
- Yaari, Roy;
- Holdridge, Karen C.;
- Andersen, Scott W.;
- Kantarci, Kejal;
- Barfield, James David;
- Jack, Clifford R.;
- Aisen, Paul S.;
- Sperling, Reisa A.
Publication type:
Article
DT‐01‐04: LANABECESTAT: BASELINE CHARACTERISTICS OF PARTICIPANTS RANDOMIZED IN THE PHASE 2/3 AMARANTH STUDY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1666, doi. 10.1016/j.jalz.2018.07.006
By:
- Sims, John R.;
- Downing, AnnCatherine M.;
- Andersen, Scott W.;
- Wessels, Alette M.;
- Zimmer, Jennifer A.;
- Mullen, Jamie;
- Schumi, Jennifer;
- Stern, Robert A.;
- Vellas, Bruno;
- Boada, Mercè;
- Cohen, Sharon;
- MacSweeney, Emer;
- Tariot, Pierre N.
Publication type:
Article
P4‐210: LANABECESTAT: SCREENING PERFORMANCE FROM THE AMARANTH STUDY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1521, doi. 10.1016/j.jalz.2018.07.031
By:
- Downing, AnnCatherine M.;
- Wessels, Alette M.;
- Zimmer, Jennifer A.;
- Nickell, Laura;
- Monroe, Katharine;
- Andersen, Scott W.;
- Mullen, Jamie;
- Sims, John R.
Publication type:
Article
P1‐039: LANABECESTAT DOES NOT AFFECT PHARMACOKINETICS OF THE BCRP SUBSTRATE ROSUVASTATIN.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P282, doi. 10.1016/j.jalz.2018.06.040
By:
- Monk, Scott A.;
- Andersen, Scott W.;
- Ayan-Oshodi, Mosun;
- Guo, Yingying;
- Hillgren, Kathleen M.;
- James, Douglas E.;
- Liffick, Emily;
- Willis, Brian A.
Publication type:
Article
THE INTEGRATED ALZHEIMER’S DISEASE RATING SCALE (IADRS): FINDINGS FROM THE EXPEDITION3 TRIAL.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1521, doi. 10.1016/j.jalz.2017.07.649
By:
- Wessels, Alette M.;
- Matthews, Brandy R.;
- Dowsett, Sherie A.;
- Andersen, Scott W.;
- Siemers, Eric R.
Publication type:
Article
DELAYED-START ANALYSES IN THE PHASE 3 SOLANEZUMAB EXPEDITION3 STUDY IN MILD ALZHEIMER’S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1260, doi. 10.1016/j.jalz.2017.06.1881
By:
- Liu-Seifert, Hong;
- Case, Michael G.;
- Andersen, Scott W.;
- Holdridge, Karen C.;
- Aisen, Paul S.;
- Kollack-Walker, Sara;
- Siemers, Eric R.
Publication type:
Article
DERIVING A CUT-OFF FOR THE ELECSYS® β-AMYLOID (1–42) IMMUNOASSAY FOR USE IN CLINICAL TRIALS SUPPORTED BY ELI LILLY FOR PATIENTS WITH CLINICALLY DEFINED ALZHEIMER’S DISEASE (AD).
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1317, doi. 10.1016/j.jalz.2017.06.2022
By:
- Shaw, Leslie M.;
- Waligorska, Teresa;
- Fields, Leona;
- Korecka, Magdalena;
- Figurski, Michal J.;
- Trojanowski, John Q.;
- Eichenlaub, Udo;
- Wahl, Simone;
- Quan, Marian;
- Lachno, David Richard;
- Talbot, Jayne A.;
- Andersen, Scott W.;
- Siemers, Eric R.;
- Dean, Robert A.
Publication type:
Article
Safety of solanezumab in the expedition-ext study up to 2 years in a mild to moderate Alzheimer’s disease population.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P741, doi. 10.1016/j.jalz.2015.06.1658
By:
- Carlson, Christopher D.;
- Sethuraman, Gopalan;
- Andersen, Scott W.;
- Holdridge, Karen C.;
- Hoog, Sharon L.;
- Hayduk, Roza;
- Siemers, Eric R.
Publication type:
Article
Delayed-start analyses of up to 3.5 years in the phase 3 solanezumab expedition program in mild Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P262, doi. 10.1016/j.jalz.2015.07.338
By:
- Liu-Seifert, Hong;
- Aisen, Paul S.;
- Andersen, Scott W.;
- Holdridge, Karen C.;
- Siemers, Eric R.
Publication type:
Article
A Novel Approach to Delayed-Start Analyses for Demonstrating Disease-Modifying Effects in Alzheimer’s Disease.
Published in:
PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0119632
By:
- Liu-Seifert, Hong;
- Andersen, Scott W.;
- Lipkovich, Ilya;
- Holdridge, Karen C.;
- Siemers, Eric
Publication type:
Article
Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes: The TRAILBLAZER-ALZ Randomized Clinical Trial.
Published in:
JAMA Neurology, 2022, v. 79, n. 10, p. 1015, doi. 10.1001/jamaneurol.2022.2793
By:
- Shcherbinin, Sergey;
- Evans, Cynthia D.;
- Lu, Ming;
- Andersen, Scott W.;
- Pontecorvo, Michael J.;
- Willis, Brian A.;
- Gueorguieva, Ivelina;
- Hauck, Paula M.;
- Brooks, Dawn A.;
- Mintun, Mark A.;
- Sims, John R.
Publication type:
Article
Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials.
Published in:
JAMA Neurology, 2020, v. 77, n. 2, p. 199, doi. 10.1001/jamaneurol.2019.3988
By:
- Wessels, Alette M.;
- Tariot, Pierre N.;
- Zimmer, Jennifer A.;
- Selzler, Katherine J.;
- Bragg, Sonja M.;
- Andersen, Scott W.;
- Landry, John;
- Krull, James H.;
- Downing, AnnCatherine M.;
- Willis, Brian A.;
- Shcherbinin, Sergey;
- Mullen, Jamie;
- Barker, Peter;
- Schumi, Jennifer;
- Shering, Craig;
- Matthews, Brandy R.;
- Stern, Robert A.;
- Vellas, Bruno;
- Cohen, Sharon;
- MacSweeney, Emer
Publication type:
Article
On the practical application of mixed effects models for repeated measures to clinical trial data.
Published in:
Pharmaceutical Statistics, 2013, v. 12, n. 1, p. 7, doi. 10.1002/pst.1548
By:
- Andersen, Scott W.;
- Millen, Brian A.
Publication type:
Article
Lanabecestat: Neuroimaging results in early symptomatic Alzheimer’s disease.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2021, v. 7, n. 1, p. 1, doi. 10.1002/trc2.12123
By:
- Zimmer, Jennifer A.;
- Shcherbinin, Sergey;
- Devous Sr., Michael D.;
- Bragg, Sonja M.;
- Selzler, Katherine J.;
- Wessels, Alette M.;
- Shering, Craig;
- Mullen, Jamie;
- Landry, John;
- Andersen, Scott W.;
- Downing, AnnCatherine M.;
- Fleisher, Adam S.;
- Otero Svaldi, Diana;
- Sims, John R.
Publication type:
Article
Clinically Negligible Pharmacokinetic and Pharmacodynamic Interactions Between Lanabecestat and Dabigatran Etexilate, a Prototypical P-gp Substrate.
Published in:
Journal of Clinical Pharmacology, 2020, v. 60, n. 5, p. 586, doi. 10.1002/jcph.1558
By:
- Monk, Scott A.;
- Kugler, Alan R.;
- Andersen, Scott W.;
- Ayan-Oshodi, Mosun A.;
- James, Douglas E.;
- Mullen, Jamie;
- Zimmer, Jennifer A.;
- Willis, Brian A.
Publication type:
Article
Assessment of Transporter Polymorphisms as a Factor in a BCRP Drug Interaction Study With Lanabecestat.
Published in:
Journal of Clinical Pharmacology, 2020, v. 60, n. 1, p. 107, doi. 10.1002/jcph.1500
By:
- Willis, Brian A.;
- Andersen, Scott W.;
- Ayan‐Oshodi, Mosun;
- James, Douglas E.;
- Liffick, Emily;
- Hillgren, Kathleen;
- Guo, Yingying;
- Monk, Scott A.
Publication type:
Article
Long-Term Safety and Tolerability of Open-Label Olanzapine Long-Acting Injection in the Treatment of Schizophrenia: 190-Week Interim Results.
Published in:
Clinical Medicine Insights: Psychiatry, 2011, n. 3, p. 37, doi. 10.4137/CMPsy.S6659
By:
- McDonnell, David P.;
- Andersen, Scott W.;
- Detke, Holland C.;
- Zhao, Fangyi;
- Watson, Susan B.
Publication type:
Article

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