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P1‐046: BASELINE CHARACTERISTICS FROM CREAD2: A PHASE III TRIAL OF CRENEZUMAB IN EARLY (PRODROMAL‐TO‐MILD) ALZHEIMER'S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P250, doi. 10.1016/j.jalz.2019.06.071
By:
- Sink, Kaycee;
- Warren, Francis;
- Smith, Jillian;
- Schneider, Andres;
- Fuji, Reina N.;
- Quartino, Angelica;
- Mackey, Howard;
- Rabbia, Michael;
- Yule, Susan;
- Fontoura, Paulo;
- Doody, Rachelle;
- Ostrowitzki, Susanne
Publication type:
Article
O1‐02‐04: BASELINE CHARACTERICS FROM A PHASE 3 TRIAL OF CRENEZUMAB IN PRODROMAL TO MILD ALZHEIMER'S DISEASE (CREAD).
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P217, doi. 10.1016/j.jalz.2018.06.2339
By:
- Lin, Helen;
- Ostrowitzki, Susanne;
- Sink, Kaycee M.;
- Millar, Laurie;
- Warren, Francis;
- Smith, Jillian;
- Schneider, Andres;
- Fuji, Reina N.;
- Quartino, Angelica;
- Mackey, Howard;
- Rabbia, Michael A.;
- Yule, Susan;
- Fontoura, Paulo;
- Doody, Rachelle
Publication type:
Article
MATHEMATICAL MODEL OF AMYLOID BETA (Aβ) DYNAMICS TO ASSESS TARGET ENGAGEMENT OF SOLUBLE Aβ OLIGOMERS BY CRENEZUMAB IN THE ALZHEIMER’S DISEASE BRAIN.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P282, doi. 10.1016/j.jalz.2017.06.176
By:
- Ferl, Gregory Z.;
- Fuji, Reina N.;
- Atwal, Jasvinder;
- Ramanujan, Saroja;
- Quartino, Angelica
Publication type:
Article
A PHASE I STUDY TO EVALUATE THE SAFETY AND TOLERABILITY OF RO7105705 IN HEALTHY VOLUNTEERS AND PATIENTS WITH MILD-TO-MODERATE AD.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P601, doi. 10.1016/j.jalz.2017.07.243
By:
- Kerchner, Geoffrey A.;
- Ayalon, Gai;
- Brunstein, Flavia;
- Chandra, Priya;
- Datwani, Akash;
- Fuji, Reina N.;
- Manser, Paul T.;
- Vaze, Anjali;
- Ward, Michael;
- Wildsmith, Kristin R.;
- Foo-Atkins, Corinne
Publication type:
Article
CLINICAL TRIAL DESIGN OF CREAD: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP PHASE 3 STUDY TO EVALUATE CRENEZUMAB TREATMENT IN PATIENTS WITH PRODROMAL-TO-MILD ALZHEIMER’S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P609, doi. 10.1016/j.jalz.2016.06.1207
By:
- Blaettler, Thomas;
- Smith, Janice;
- Smith, Jillian;
- Paul, Robert;
- Asnaghi, Veronica;
- Fuji, Reina;
- Quartino, Angelica;
- Honigberg, Lee;
- Jr.Rabbia, Michael A.;
- Yule, Susan;
- Ostrowitzki, Susanne;
- Fontoura, Paulo
Publication type:
Article
Injectable Polymer‐Nanoparticle Hydrogel for the Sustained Intravitreal Delivery of Bimatoprost.
Published in:
Advanced Therapeutics, 2023, v. 6, n. 2, p. 1, doi. 10.1002/adtp.202200207
By:
- Meany, Emily L.;
- Andaya, Roxanne;
- Tang, Shijia;
- Kasse, Catherine M.;
- Fuji, Reina N.;
- Grosskopf, Abigail K.;
- d'Aquino, Andrea L.;
- Bartoe, Joshua T.;
- Ybarra, Ryan;
- Shelton, Amy;
- Pederson, Zachary;
- Hu, Chloe;
- Leung, Dennis;
- Nagapudi, Karthik;
- Ubhayakar, Savita;
- Wright, Matthew;
- Yen, Chun‐Wan;
- Appel, Eric A.
Publication type:
Article
Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial.
Published in:
JAMA Neurology, 2022, v. 79, n. 8, p. 758, doi. 10.1001/jamaneurol.2022.1375
By:
- Teng, Edmond;
- Manser, Paul T.;
- Pickthorn, Karen;
- Brunstein, Flavia;
- Blendstrup, Mira;
- Sanabria Bohorquez, Sandra;
- Wildsmith, Kristin R.;
- Toth, Bali;
- Dolton, Michael;
- Ramakrishnan, Vidya;
- Bobbala, Ashwini;
- Sikkes, Sietske A. M.;
- Ward, Michael;
- Fuji, Reina N.;
- Kerchner, Geoffrey A.
Publication type:
Article
Evolutionary conservation of histone macroH2A subtypes and domains.
Published in:
Nucleic Acids Research, 1998, v. 26, n. 12, p. 2837, doi. 10.1093/nar/26.12.2837
By:
- Pehrson, John R.;
- Fuji, Reina N.
Publication type:
Article
Assessment of Color Reproducibility and Mitigation of Color Variation in Whole Slide Image Scanners for Toxicologic Pathology.
Published in:
Toxicologic Pathology, 2023, v. 51, n. 6, p. 313, doi. 10.1177/01926233231224468
By:
- Chu, Mei-Lan;
- Ge, Xing-Yue M.;
- Eastham, Jeffrey;
- Nguyen, Trung;
- Fuji, Reina N.;
- Sullivan, Ruth;
- Ruderman, Daniel
Publication type:
Article
Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry.
Published in:
Toxicologic Pathology, 2022, v. 50, n. 8, p. 942, doi. 10.1177/01926233221132747
By:
- Ge, Xing-Yue;
- Funk, Juergen;
- Albrecht, Tom;
- Birkhimer, Merima;
- Gilsdorf, Moritz;
- Hayes, Matthew;
- Hu, Fangyao;
- Maliver, Pierre;
- McCreary, Mark;
- Nguyen, Trung;
- Romero-Palomo, Fernando;
- Seger, Shanon;
- Fuji, Reina N.;
- Schumacher, Vanessa;
- Sullivan, Ruth
Publication type:
Article
LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits.
Published in:
Science Translational Medicine, 2020, v. 12, n. 540, p. 1, doi. 10.1126/scitranslmed.aav0820
By:
- Baptista, Marco A. S.;
- Merchant, Kalpana;
- Barrett, Ted;
- Bhargava, Sakshi;
- Bryce, Dianne K.;
- Ellis, J. Michael;
- Estrada, Anthony A.;
- Fell, Matthew J.;
- Fiske, Brian K.;
- Fuji, Reina N.;
- Galatsis, Paul;
- Henry, Anastasia G.;
- Hill, Sue;
- Hirst, Warren;
- Houle, Christopher;
- Kennedy, Matthew E.;
- Liu, Xingrong;
- Maddess, Matthew L.;
- Markgraf, Carrie;
- Mei, Hong
Publication type:
Article
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.
Published in:
Science Translational Medicine, 2015, v. 7, n. 273, p. 1, doi. 10.1126/scitranslmed.aaa3634
By:
- Fuji, Reina N.;
- Flagella, Michael;
- Baca, Miriam;
- Baptista, Marco A. S.;
- Brodbeck, Jens;
- Chan, Bryan K.;
- Fiske, Brian K.;
- Honigberg, Lee;
- Jubb, Adrian M.;
- Katavolos, Paula;
- Lee, Donna W.;
- Sock-Cheng Lewin-Koh;
- Tori Lin;
- Xingrong Liu;
- Shannon Liu;
- Lyssikatos, Joseph P.;
- O’Mahony, Jennifer;
- Reichelt, Mike;
- Roose-Girma, Merone;
- Zejuan Sheng
Publication type:
Article
Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid.
Published in:
Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 4, p. 826, doi. 10.1002/cpt.2531
By:
- Sadekar, Shraddha S.;
- Bowen, Mayumi;
- Cai, Hao;
- Jamalian, Samira;
- Rafidi, Hanine;
- Shatz‐Binder, Whitney;
- Lafrance‐Vanasse, Julien;
- Chan, Pamela;
- Meilandt, William J.;
- Oldendorp, Amy;
- Sreedhara, Alavattam;
- Daugherty, Ann;
- Crowell, Susan;
- Wildsmith, Kristin R.;
- Atwal, Jasvinder;
- Fuji, Reina N.;
- Horvath, Joshua
Publication type:
Article
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 1, p. 62, doi. 10.1002/psp4.12876
By:
- Ramakrishnan, Vidya;
- Friedrich, Christina;
- Witt, Colleen;
- Sheehan, Robert;
- Pryor, Meghan;
- Atwal, Jasvinder K.;
- Wildsmith, Kristin;
- Kudrycki, Katherine;
- Lee, Seung‐Hye;
- Mazer, Norman;
- Hofmann, Carsten;
- Fuji, Reina N.;
- Jin, Jin Y.;
- Ramanujan, Saroja;
- Dolton, Michael;
- Quartino, Angelica
Publication type:
Article
Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates.
Published in:
2017
By:
- Yadav, Daniela Bumbaca;
- Maloney, Janice A;
- Wildsmith, Kristin R;
- Fuji, Reina N;
- Meilandt, William J;
- Solanoy, Hilda;
- Lu, Yanmei;
- Peng, Kun;
- Wilson, Blair;
- Chan, Pamela;
- Gadkar, Kapil;
- Kosky, Andrew;
- Goo, Marisa;
- Daugherty, Ann;
- Couch, Jessica A;
- Keene, Thomas;
- Hayes, Karen;
- Nikolas, Lisa Jungbauer;
- Lane, Deanna;
- Switzer, Robert
Publication type:
journal article
Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier.
Published in:
Science Translational Medicine, 2013, v. 5, n. 183, p. 1, doi. 10.1126/scitranslmed.3005338
By:
- Couch, Jessica A.;
- Yu, Y. Joy;
- Yin Zhang;
- Tarrant, Jacqueline M.;
- Fuji, Reina N.;
- Meilandt, William J.;
- Solanoy, Hilda;
- Tong, Raymond K.;
- Kwame Hoyte;
- Luk, Wilman;
- Yanmei Lu;
- Gadkar, Kapil;
- Prabhu, Saileta;
- Ordonia, Benjamin A.;
- Nguyen, Quyen;
- Yuwen Lin;
- Zhonghua Lin;
- Balazs, Mercedesz;
- Scearce-Levie, Kimberly;
- Ernst, James A.
Publication type:
Article
An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2.
Published in:
British Journal of Pharmacology, 2013, v. 168, n. 2, p. 445, doi. 10.1111/j.1476-5381.2012.02138.x
By:
- Boswell, C Andrew;
- Mundo, Eduardo E;
- Firestein, Ron;
- Zhang, Crystal;
- Mao, Weiguang;
- Gill, Herman;
- Young, Cynthia;
- Ljumanovic, Nina;
- Stainton, Shannon;
- Ulufatu, Sheila;
- Fourie, Aimee;
- Kozak, Katherine R;
- Fuji, Reina;
- Polakis, Paul;
- Khawli, Leslie A;
- Lin, Kedan
Publication type:
Article
The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell-surface-targeted biological agents in patients.
Published in:
British Journal of Pharmacology, 2012, v. 166, n. 5, p. 1600, doi. 10.1111/j.1476-5381.2012.01916.x
By:
- Polson, Andrew G;
- Fuji, Reina N
Publication type:
Article
Analysis of cellularity in H&E-stained rat bone marrow tissue via deep learning.
Published in:
Journal of Pathology Informatics, 2023, v. 14, p. 1, doi. 10.1016/j.jpi.2023.100333
By:
- Shiffman, Smadar;
- Rios Piedra, Edgar A.;
- Adedeji, Adeyemi O.;
- Ruff, Catherine F.;
- Andrews, Rachel N.;
- Katavolos, Paula;
- Liu, Evan;
- Forster, Ashley;
- Brumm, Jochen;
- Fuji, Reina N.;
- Sullivan, Ruth
Publication type:
Article

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