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- Title
Quaternary ammonium‐based mitochondria targeting anticancer agents with high water solubility.
- Authors
Kim, Sangpil; Yoon, Nam Gu; Jana, Batakrishna; Kang, Byoung Heon; Ryu, Ja‐Hyoung
- Abstract
Triphenylphosphonium derivatives induce mitochondrial dysfunction by inhibiting the respiratory chain, membrane depolarization, and generation of reactive oxygen species. However, the clinical application has been limited due to low aqueous solubility. In this regard, a series of novel mitochondria targeting agents were designed by introducing quaternary ammonium that increases aqueous solubility. Among them, diquaternary ammonium containing triphenylphosphonium molecules specifically inhibited mitochondrial respiratory chain, disrupted mitochondrial proteostasis, and intra‐mitochondrial protein in cancer cells, resulting in apoptosis induction. Overall, the high water‐soluble mitochondria targeting agents would be a potential anticancer drug.
- Subjects
MITOCHONDRIA; ANTINEOPLASTIC agents; SOLUBILITY; REACTIVE oxygen species; PLANT mitochondria
- Publication
Bulletin of the Korean Chemical Society, 2022, Vol 43, Issue 3, p391
- ISSN
0253-2964
- Publication type
Article
- DOI
10.1002/bkcs.12482