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- Title
Co-circulation of coxsackieviruses A-6, A-10, and A-16 causes hand, foot, and mouth disease in Guangzhou city, China.
- Authors
Xie, Jia; Yang, Xiao-Han; Hu, Si-Qi; Zhan, Wen-Li; Zhang, Chang-Bin; Liu, Hong; Zhao, Hong-Yu; Chai, Hui-Ying; Chen, Ke-Yi; Du, Qian-Yi; Liu, Pan; Yin, Ai-Hua; Luo, Ming-Yong
- Abstract
<bold>Background: </bold>Hand, foot, and mouth disease (HFMD) is a common infectious disease occurring in children under 5 years of age worldwide, and Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CVA-16) are identified as the predominant pathogens. In recent years, Coxsackievirus A6 (CVA-6) and Coxsackievirus A10 (CVA-10) have played more and more important role in a series of HFMD outbreaks. This study aimed to understand the epidemic characteristics associated with HFMD outbreak in Guangzhou, 2018.<bold>Methods: </bold>The clinical and laboratory data of 1220 enterovirus-associated HFMD patients in 2018 were analysed in this study. Molecular diagnostic methods were performed to identify its serotypes. Phylogenetic analyses were depicted based on the complete VP1 gene.<bold>Results: </bold>There were 21 enterovirus serotypes detected in Guangzhou in 2018. Three serotypes of enterovirus, CVA-6 (364/1220, 29.8%), CVA-10 (305/1220, 25.0%), and CVA-16 (397/1220, 32.5%), were identified as the causative pathogens and accounted for 87.3% among all 1220 HFMD patients. In different seasons, CVA-6 was the predominant pathogen of HFMD during autumn, and CVA-10 as well as CVA-16 were more prevalent in summer. Patients infected by CVA-6, CVA-10 or CVA-16 showed similar clinical features and laboratory characteristics, and the ratios of severe HFMD were 5.8, 5.9, and 1.5% in the three serotypes. Phylogenetic analyses of VP1 sequences showed that the CVA-6, CVA-10, and CVA-16 sequences belonged to the sub-genogroup E2, genogroup E, and genogroup B1, respectively.<bold>Conclusions: </bold>CVA-6, CVA-10, and CVA-16 were the predominant and co-circulated serotypes in Guangzhou China, 2018, which should be the new target for prevention and control of HFMD. Our findings provide useful information for diagnosis, treatment, and prevention of HFMD.
- Subjects
GUANGZHOU (China); CHINA; COXSACKIEVIRUS diseases; FOOT; JUVENILE diseases; COMMUNICABLE diseases; PATHOLOGICAL laboratories; SEROTYPES; ENTEROVIRUSES; PROTEINS; BIOLOGICAL evolution; HAND, foot &; mouth disease; NUCLEOTIDES; SEASONS; EPIDEMICS; DISEASE prevalence; GENOTYPES; RESEARCH funding
- Publication
BMC Infectious Diseases, 2020, Vol 20, Issue 1, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-020-04992-x