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- Title
Myrtle (Myrtus communis) leaf extract suppresses hepatotoxicity induced by monosodium glutamate and acrylamide through obstructing apoptosis, DNA fragmentation, and cell cycle arrest.
- Authors
Hassan, Hanaa A.; EL-Kholy, Wafaa M.; EL-Sawi, Mamdouh R. F.; Galal, Nadine A.; Ramadan, Mohamed Fawzy
- Abstract
A large number of plant extracts have demonstrated to provide health benefits and mitigate several disease conditions. However, at the molecular and cellular levels, few studies have been conducted. The present work was designed to study the effect of Myrtus communis leaf extract (ME) (300 mg/kg bw) against hepatotoxicity induced by monosodium glutamate (MSG) (100 mg/kg bw), and acrylamide (ACR) (20 mg/kg bw) in male rats and determining its molecular and cellular mechanisms. The data showed that the treatment with MSG and/or ACR induced significant changes in numerous biomarkers (Bcl-2 and the programmed cell death protein-1) related to liver damage, as recorded by genotoxicity, apoptosis, and histopathological changes. On the other side, the oral administration of ME (300 mg/kg bw) improved the hepatic conditions as confirmed by the improvement in cell viability, programmed cell death, and histopathological alterations. It can be concluded that the consumption of ME might be useful for minimizing the occurred hepatotoxicity through up-regulation of the key apoptotic regulators as well as the improvement of DNA content and cell cycle restoration.
- Subjects
MONOSODIUM glutamate; CELL cycle; HEPATOTOXICOLOGY; PLANT DNA; MYRTLE (Plants); APOPTOSIS; ACRYLAMIDE; DNA
- Publication
Environmental Science & Pollution Research, 2020, Vol 27, Issue 18, p23188
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-020-08780-7