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- Title
Mechanistic Insights into the Interface‐Directed Transformation of Thiols into Disulfides and Molecular Hydrogen by Visible‐Light Irradiation of Quantum Dots.
- Authors
Li, Xu‐Bing; Li, Zhi‐Jun; Gao, Yu‐Ji; Meng, Qing‐Yuan; Yu, Shan; Weiss, Richard G.; Tung, Chen‐Ho; Wu, Li‐Zhu
- Abstract
Quantum dots (QDs) offer new and versatile ways to harvest light energy. However, there are few examples involving the utilization of QDs in organic synthesis. Visible‐light irradiation of CdSe QDs was found to result in virtually quantitative coupling of a variety of thiols to give disulfides and H2 without the need for sacrificial reagents or external oxidants. The addition of small amounts of nickel(II) salts dramatically improved the efficiency and conversion through facilitating the formation of hydrogen atoms, thereby leading to faster regeneration of the ground‐state QDs. Mechanistic studies reveal that the coupling reaction occurs on the QD surfaces rather than in solution and offer a blueprint for how these QDs may be used in other photocatalytic applications. Because no sacrificial agent or oxidant is necessary and the catalyst is reusable, this method may be useful for the formation of disulfide bonds in proteins as well as in other systems sensitive to the presence of oxidants.
- Subjects
QUANTUM dots; ENERGY harvesting; ORGANIC synthesis; HYDROGEN atom; IRRADIATION; DISULFIDES
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 8, p2117
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201310249