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- Title
Hypothermic Perfusion Modifies the Association Between Anti-LG3 Antibodies and Delayed Graft Function in Kidney Recipients.
- Authors
Mawad, Habib; Pinard, Louis; Medani, Samar; Chagnon, Miguel; Boucquemont, Julie; Turgeon, Julie; Dieudé, Mélanie; Hamelin, Katia; Rimbaud, Annie Karakeussian; Belayachi, Ali; Bing Yang; Collette, Suzon; Sénécal, Lynne; Foster, Bethany J.; Hébert, Marie-Josée; Cardinal, Héloïse
- Abstract
We previously reported associations between autoantibodies to the LG3 fragment of perlecan, anti-LG3, and a higher risk of delayed graft function (DGF) in kidney transplant recipients. Here, we aimed to determine whether some factors that modulate ischemiareperfusion injury (IRI) can modify this association. We performed a retrospective cohort study in kidney transplant recipients in 2 university-affiliated centers. In 687 patients, we show that high pre-transplant anti-LG3 are associated with DGF when the kidney is transported on ice (odds ratio (OR): 1.75, 95% confidence interval 1.02-3.00), but not when placed on hypothermic perfusion pump (OR: 0.78, 95% CI 0.43-1.37). In patients with DGF, high pre-transplant anti-LG3 are associated with a higher risk of graft failure (subdistribution hazard ratio (SHR): 4.07, 95% CI: 1.80, 9.22), while this was not the case in patients with immediate graft function (SHR: 0.50, 95% CI 0.19, 1.29). High anti-LG3 levels are associated with a higher risk of DGF in kidneys exposed to cold storage, but not when hypothermic pump perfusion is used. High anti-LG3 are also associated with a higher risk of graft failure in patients who experience DGF, a clinical manifestation of severe IRI.
- Subjects
DRUG infusion pumps; PERFUSION; IMMUNOGLOBULINS; KIDNEY transplantation; COLD storage
- Publication
Transplant International, 2023, Vol 36, p1
- ISSN
0934-0874
- Publication type
Article
- DOI
10.3389/ti.2023.10749