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- Title
Characterization of excretory/secretory products of the Taenia crassiceps cysticercus involved in the induction of regulatory T cells in vivo.
- Authors
Morales-Ruiz, Valeria; López-Recinos, Dina; Castañeda, María Gracia; Guevara-Salinas, Adrián; Parada-Colin, Cristina; Gómez-Fuentes, Sandra; Espitia-Pinzón, Clara; Hernández-González, Marisela; Adalid-Peralta, Laura
- Abstract
The ability to modulate the host immune response has allowed some parasites to establish themselves in the tissues of an immunocompetent organism. While some parasite excretion/secretion products (ESPs) were recently reported to induce differentiation of regulatory T cells (Tregs), their identity is not known. This work is aimed to identify and characterize ESPs of Taenia crassiceps cysticerci linked with Treg induction in vivo. ESPs were obtained from cultures of T. crassiceps cysticerci and inoculated in mice, measuring Treg levels by flow cytometry. Proteins in ESPs were analyzed by electrophoresis; then, ESPs were classified as either differential or conserved. Differentially included proteins were MS-sequenced and functionally characterized. Only 4 of 10 ESPs induced Tregs. Proteins with catalytic activity and those involved in immunological processes predominated, supporting the idea that these molecules could play an important role in the induction of Tregs.
- Subjects
REGULATORY T cells; T cells; TAENIA; T cell differentiation; IMMUNE response; CATALYTIC activity
- Publication
Parasitology Research, 2023, Vol 122, Issue 7, p1489
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-023-07847-x