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- Title
PD-1, PD-L1 and cAMP immunohistochemical expressions are associated with worse oncological outcome in patients with bladder cancer.
- Authors
Russo, Giorgio Ivan; Musso, Nicolò; Lo Giudice, Arturo; Asmundo, Maria Giovanna; Di Mauro, Marina; Bonacci, Paolo G.; Massimino, Mariacristina; Bivona, Dalida; Stefani, Stefania; Pricoco, Elisabetta; Ferro, Matteo; Camarda, Massimo; Cimino, Sebastiano; Morgia, Giuseppe; Caltabiano, Rosario; Broggi, Giuseppe
- Abstract
Purpose: In this study, we aimed to identify prognostic factors of cancer mortality in patients who received radical cystectomy and to identify genomic alterations in a sub-cohort of patients with locally advanced (pT3-4) and/or positive lymph nodes bladder cancer (BC). Methods: We collected 101 BC samples from 2010 to 2018 who previously received radical cystectomy. Immunohistochemical slides were evaluated for PPAR, cAMP, IMP3, Ki67, CDK4, POU5F1, Cyclin E and MDM2, p65, CD3, CD4, CD8, CD20, CD68, CD163, FOXP3, PD-1 and PD-L1 expression. We calculated a prognostic score (PS) based on the positivity to PD-1, PD-L1 and of cAMP (final score ranging from 0 to 3). DNA of each sample have been used for sequencing by NGS in a sub-cohort of 6 patients with locally advanced (pT3-4) and/or positive lymph nodes BC. Results: PD-1 + (HR [hazard ratio] 2.59; p = 0.04), PD-L1+ (HR = 6.46; p < 0.01) and cAMP+ (HR 3.04; p = 0.02) were independent predictors of cancer-specific mortality (CSM). Increase of PS (score = 0 as reference) was associated with CSM, 0.81 (p = 0.80), 4.72 (p = 0.01) and 10.51 (p < 0.0) for PS 1, 2 and 3, respectively. ERBB2 was the gene most frequently mutated. Conclusion: BC exhibited heterogenous protein expression and variable genomic features. Identification of expression of PD-1, PD-L1 and cAMP could help in predicting oncological outcomes.
- Subjects
PROGRAMMED cell death 1 receptors; PROGRAMMED death-ligand 1; CANCER patients; CANCER prognosis; LYMPH node cancer
- Publication
Journal of Cancer Research & Clinical Oncology, 2023, Vol 149, Issue 7, p3681
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-022-04262-0