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- Title
A new dye based on anthocyanins from the acai fruit (Euterpe oleracea) for chromovitrectomy in humans: clinical trial results.
- Authors
Caiado, Rafael R.; Peris, Cristiane; Rodrigues, Eduardo B.; Farah, Michel Eid; Maia, André; Magalhães, Octaviano; Novais, Eduardo; Lima-Filho, Acácio Souza; Maia, Mauricio
- Abstract
Purpose: To test the applicability of the acai dye at a 25% concentration for identifying the posterior hyaloids and internal limiting membranes (ILMs) during pars plana vitrectomy (PPV) in human eyes with macular holes (MHs).Methods: This study included 25 patients with chronic idiopathic MHs. The exclusion criteria included glaucoma, previous significant ocular conditions, and previous ocular surgeries except uncomplicated cataract. Ten surgeons performed 23-gauge four-port PPV, phacoemulsification, posterior hyaloid detachment, ILM peeling guided by dye staining, and perfluoropropane injection. The patients remained prone for 5 days postoperatively. The patients were evaluated postoperatively after 1, 30, and 180 days. The surgeons completed a questionnaire regarding the dye's staining abilities.Results: The posterior hyaloids and ILMs stained purple in all eyes. The final best-corrected visual acuity improved significantly (p < 0.001) from preoperatively (1.37 ± 0.29) to 180 days postoperatively (1.05 ± 0.43). The MHs closed in 76% of eyes.Conclusion: The acai dye at a 25% concentration identified posterior hyaloids and ILMs during PPVs in humans. Dye toxicity was unlikely.
- Subjects
DYES &; dyeing; CLINICAL trials; VISUAL acuity; FRUIT
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2019, Vol 257, Issue 3, p517
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-018-04204-y